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■GMP grade Holotransferrin, human, sterile |
 Mebiopharm Co., Ltd., Japan is pleased to announce that we can supply and sell GMP grade of human holotransferrin to worldwide customers.
Representing a blood plasma glycoprotein (MW: near 80,000) for iron ion delivery, Transferrin possesses 2 affinity binding sites with Fe (Ⅲ).
Transferrin can be used as tumor targeting ligand for cytotoxic drug or siRNA delivery. And another beneficial usage of human holotransferrin is for cell culture to promote the yield of biological products. However resources of human holotransferrin were limited and non GMP grade was only available from human blood until now.
When a transferrin protein loaded with iron encounters a transferrin receptor on the surface of a cell, it binds to receptor and is consequently transported into the cell in a vesicle. The cell will acidify the vesicle, causing transferrin to release its iron ions. The receptor is then transported through the endocytic cycle back to the cell surface, ready for another round of transferrin uptake.
It is well known that many tumor cells are abundant in transferrin receptors for angiogenesis. Following charts represent how specific tumors have large number of receptors in comparison with normal cells.
When liposome attached with Transferrin is applied to tumor, liposome will be captured by tumor cells through endocytosis as shown in the following electron microscopic picture.
Not only liposomes but also other type of particles can be delivered to tumor cells as long as transferrin is attached on the surface of particles as described in the reference.
| Reference |
: H. Iinuma et al, Int. J. Cancer; 99, 130-137 (2002) |
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: S. Hu-Lieskovan et al, Cancer Res.; 65: (19), 8984-8982 (2005) |
| Followings are related information in which transferrin is utilized for targeting.
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: Debinski, W., Cancer Invest. 20, 801-809 (2002) |
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: Ng, P. et al, Proc. Natl. Acad. Sci. USA 99, 10706-10711 (2002) |
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: White, S. et al, Cancer Res. 50, 6295-6301 (1990) |
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: Kawabata, H. et al, J. Biol. Chem. 275, 16618-16625 (2000) |
| http://www.pharm.teikyo-u.ac.jp/lab/s-yakuzai/jour.html |
| http://www.nature.com/gt/journal/v9/n11/full/3301748a.html |
| http://www.springerlink.com/content/m1rg64151nu017q3/ |
Sanquin developed GMP purification process and Mebiopharm would supply and sell their best quality products world wide.
About Sanquin
Established through a merger between the Dutch Blood Banks and the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service (CLB), Sanquin is a not-for-profit foundation assigned by the Dutch government to ensure a safe and efficient blood supply in the Netherlands. Sanquin activities include manufacturing and sales of blood products and plasma-derived products,diagnostic services and carrying out contract services.
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