GMP grade Holotransferrin, human,
sterile:
Mebiopharm is an exclusive supplier of GMP
grade Holotransferrin manufactured by Sanquin
blood supply foundation in the Netherlands
*.
Transferrin is a key molecule as
a ligand for DDS; it is also used for cell
cultures to produce recombinant proteins.
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Transferrin is a blood plasma glycoprotein
(MW: near 80,000) for ferric ion
delivery which possesses 2 affinity
binding sites with Fe(III)
Transferrin is effective to be used as a
tumor targeting ligand for cytotoxic drug or
siRNA delivery.
When a transferrin loaded with ferric
ions encounters a transferrin receptor on the
surface of a cell, it binds to the receptor and
is transported into the cell as a vesicle. Since
it is acidic in human cell, transferrin releases
its ferric ions. The receptor is then
transported back to the cell surface through the
endocytic cycle, ready for another round of
transferrin uptake.
It is well known that tumor cells are
abundant in transferrin receptors for
angiogenesis compared with normal cells.
(diagram A).
When substances attached with Transferrin are
applied to a tumor, they are captured by tumor
cells through endocytosis (diagram
B).
Reference
: H. Iinuma et al, Int. J.
Cancer; 99, 130-137 (2002)
: S. Hu-Lieskovan
et al, Cancer Res.; 65: (19), 8984-8982 (2005)
The following is related information in
which transferrin is utilized for
targeting:
: Debinski, W., Cancer Invest. 20,
801-809 (2002)
: Ng, P. et al, Proc. Natl.
Acad. Sci. USA 99, 10706-10711 (2002)
:
White, S. et al, Cancer Res. 50, 6295-6301
(1990)
: Kawabata, H. et al, J. Biol. Chem.
275, 16618-16625 (2000)
Links
: Publication list from Teikyo
Univ. Faculty of Pharmaceutical Science:
Laboratory of Biopharmaceutics
: Article in "Gene Therapy" from
Nature Publishing Group
: Article in Pharmaceutical
Reserch from Springer Netherland
Established through a merger between the
Dutch Blood Banks and the Central Laboratory of
the Netherlands Red Cross Blood Transfusion
Service (CLB), Sanquin is a
not-for-profit foundation assigned by the Dutch
government to ensure a safe and efficient blood
supply in the Netherlands. Sanquin activities
include manufacturing and sales of blood
products and plasma-derived products, diagnostic
services and carrying out contract
services.
